CUDC-101

  • Chemical Properties
CAS No. 1012054-59-9 Cat. No. BCP01935
Name CUDC-101
Synonyms CUDC101;CUDC 101;
Formula C24H26N4O4 M. Wt 434.49
  • Biological Activity
Description CUDC-101 is a multi-targeted, small-molecule inhibitor of histone deacetylase (HDAC), epidermal growth factor receptor tyrosine kinase (EGFR/ErbB1), and human epidermal growth factor receptor 2 tyrosine kinase (HER2/neu or ErbB2) with potential antineoplastic activity. HDAC/EGFR/HER2 inhibitor CUDC-101 inhibits the activity of these three enzymes but the exact mechanism of action is presently unknown. This agent may help overcome resistance to inhibition of EGFR and Her2 through a simultaneous, synergistic inhibition of EGFR, Her2, and HDAC.
Pathways Angiogenesis/Protein Tyrosine Kinase Cell Cycle/DNA Damage Jak/Stat Pathway Epigenetics 
Targets HDAC EGFR HER2 

Structure

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