Fasudil hydrochloride

  • Chemical Properties
CAS No. 105628-07-7 Cat. No. BCP26351
Name Fasudil hydrochloride
Synonyms HA-1077;HA 1077;HA1077; AT 877; AT877; AT-877; Fasudil HCl;
Formula C14H17N3O2S.HCl M. Wt 327.83
  • Biological Activity
Description Fasudil, also known as HA-1077, is a potent Rho-kinase inhibitor and vasodilator. Since it was discovered, it has been used for the treatment of cerebral vasospasm, which is often due to subarachnoid hemorrhage, as well as to improve the cognitive decline seen in stroke victims. It has been found to be effective for the treatment of pulmonary hypertension. It was demonstrated in February 2009 that fasudil could also be used to enhance memory and improve the prognosis of Alzheimers patients. It is approved for use in Japan and China.
Pathways Cell Cycle/DNA Damage Others Pathway TGF beta/Smad  GPCR/G Protein Wnt/Stem Cell 
Targets Autophagy ROCK PKA 
  • Publications Citing
Suppression of glioblastoma by a drug cocktail reprogramming tumor cells into neuronal like cells

Publications Citing of Biochempartner's Fasudil hydrochloride(CAS:105628-07-7)

Structure

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