Oxocarbazate 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP42707CAS号：1014405-03-8纯度：98%

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CAS号	1014405-03-8	货号	BCP42707
中文名	Oxocarbazate
英文名	Oxocarbazate
中文别名
英文别名	CID 23631927; CID23631927; CID-23631927;
SMILES	CC(C)(C)OC(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NNC(=O)OCC(=O)N3CCCC4=CC=CC=C43
化学名称
分子式	C28H33N5O6	分子量	535.6
纯度	98%	配送	惯例下常温包邮
产品描述	Oxocarbazate is an inhibitor of human cathepsin L. In the cathepsin L inhibition assay, The oxocarbazate caused a time-dependent 17-fold drop in IC50 from 6.9 nM (no preincubation) to 0.4 nM (4-h preincubation). Slowly reversible inhibition was demonstrated in a dilution assay. CID23631927 demonstrate activity in blocking both SARS-CoV (IC50 = 273 nM) and Ebola virus (IC50 = 193 nM) entry into human embryonic. CID 23631927 was a subnanomolar, slow-binding, reversible inhibitor of human cathepsin L that blocked SARS-CoV and Ebola pseudotype virus entry in human cells. Inhibition of cathepsin L thus holds promise for therapeutic intervention for both SARS-CoV and Ebola virus infection.