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| CAS号 | 1204669-58-8 | 货号 | BCP14546 |
| 中文名 | Epacadostat | ||
| 英文名 | Epacadostat | ||
| 中文别名 | |||
| 英文别名 | INCB024360; INCB 024360; INCB-024360; INCB24360; INCB-24360; INCB 24360; IDO inhibitor 1; | ||
| SMILES | BrC =C(F)C=CC(N/C(C2=N | ||
| 化学名称 | |||
| 分子式 | C11H13BrFN7O4S | 分子量 | 438.23 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | Epacadostat, also known as INCB024360 or INCB24360, is an orally available hydroxyamidine and inhibitor of indoleamine 2,3-dioxygenase (IDO1), with potential immunomodulating and antineoplastic activities. INCB024360 targets and binds to IDO1, an enzyme responsible for the oxidation of tryptophan into kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, INCB024360 increases and restores the proliferation and activation of various immune cells, including dendritic cells (DCs), NK cells, and T-lymphocytes, as well as interferon (IFN) production, and a reduction in tumor-associated regulatory T cells (Tregs). | ||
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