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| CAS号 | 1216720-69-2 | 货号 | BCP46793 |
| 关联产品 | 245520-69-8（SCH 79797） | ||
| 中文名 | SCH 79797 dihydrochloride | ||
| 英文名 | SCH 79797 dihydrochloride | ||
| 中文别名 | |||
| 英文别名 | SCH 79797 2HCl;SCH79797 2HCl; | ||
| SMILES | CC(C)C1=CC=C(C=C1)CN2C=CC3=C2C=CC4=C3C(=NC(=N4)NC5CC5)N.Cl.Cl | ||
| 化学名称 | |||
| 分子式 | C23H27Cl2N5 | 分子量 | 444.41 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | SCH79797 dihydrochloride is a highly potent, selective nonpeptide protease activated receptor 1 (PAR1) antagonist. SCH79797 dihydrochloride inhibits binding of a high-affinity thrombin receptor-activating peptide to PAR1 with an IC50 of 70 nM and a Ki of 35 nM. SCH79797 dihydrochloride inhibits thrombin-induced platelet aggregation with an IC50 of 3 μM. SCH79797 dihydrochloride has antiproliferative and pro-apoptotic effects, and limits myocardial ischemia/reperfusion injury in rat hearts. SCH79797 dihydrochloride also potently prevents PAR1 activation in vascular smooth muscle cells, endothelial cells, and astrocytes. | ||
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