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| CAS号 | 1428774-45-1 | 货号 | BCP44108 |
| 中文名 | PF-06459988 | ||
| 英文名 | PF-06459988 | ||
| 中文别名 | |||
| 英文别名 | PF06459988; PF 06459988; PF-6459988; PF 6459988; PF6459988; | ||
| SMILES | CN1C=C(C=N1)NC2=NC3=C(C(=CN3)Cl)C(=N2)OCC4CN(CC4OC)C(=O)C=C | ||
| 化学名称 | |||
| 分子式 | C19H22ClN7O3 | 分子量 | 431.88 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | PF-06459988 is an orally available, small molecule, third-generation, irreversible inhibitor of epidermal growth factor receptor (EGFR) mutant (EGFRm) forms with potential antineoplastic activity. EGFR inhibitor PF-06459988 specifically binds to and inhibits mutant forms of EGFR, including the secondary acquired resistance mutation T790M, which prevents EGFR-mediated signaling and leads to cell death in EGFRm-expressing tumor cells. Compared to some other EGFR inhibitors, PF-06459988 may have therapeutic benefits in tumors with T790M-mediated drug resistance. | ||
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