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PF-06409577 结构式

PF-06409577

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货号 :BCP32554CAS号 :1467057-23-3纯度:98%
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  • 基本信息与产品描述
CAS号 1467057-23-3 货号 BCP32554
中文名 PF-06409577
英文名 PF-06409577
中文别名
英文别名 PF06409577; PF 06409577; PF-6409577; PF6409577; PF 6409577;
SMILES C1CC(C1)(C2=CC=C(C=C2)C3=C(C=C4C(=C3)C(=CN4)C(=O)O)Cl)O
化学名称
分子式 C19H16ClNO3 分子量 341.79
纯度 98% 配送 惯例下常温包邮
产品描述 PF-06409577 is a potent and selective activator of 5′ adenosine monophosphate-activated protein kinase (AMPK) for the Potential Treatment of diabetic nephropathy. PF-06409577 has AMPK α1β1γ1 Kd=9.0 nM. AMPK α1β1γ1 EC50 = 7.0 nM; AMPK α1β2γ1 EC50 > 40000 nM. PF-06409577 showed efficacy in a preclinical model of diabetic nephropathy. Upon the basis of its potent and selective AMPK activation, low metabolic turnover in human hepatocytes, clean off-target profile, and favorable preclinical in vivo efficacy results, PF-06409577 was profiled in regulatory toxicology studies and was subsequently advanced to clinical trials to assess human pharmacokinetics and safety/ tolerability.
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