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CAS号 | 1467057-23-3 | 货号 | BCP32554 |
中文名 | PF-06409577 | ||
英文名 | PF-06409577 | ||
中文别名 | |||
英文别名 | PF06409577; PF 06409577; PF-6409577; PF6409577; PF 6409577; | ||
SMILES | C1CC(C1)(C2=CC=C(C=C2)C3=C(C=C4C(=C3)C(=CN4)C(=O)O)Cl)O | ||
化学名称 | |||
分子式 | C19H16ClNO3 | 分子量 | 341.79 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | PF-06409577 is a potent and selective activator of 5′ adenosine monophosphate-activated protein kinase (AMPK) for the Potential Treatment of diabetic nephropathy. PF-06409577 has AMPK α1β1γ1 Kd=9.0 nM. AMPK α1β1γ1 EC50 = 7.0 nM; AMPK α1β2γ1 EC50 > 40000 nM. PF-06409577 showed efficacy in a preclinical model of diabetic nephropathy. Upon the basis of its potent and selective AMPK activation, low metabolic turnover in human hepatocytes, clean off-target profile, and favorable preclinical in vivo efficacy results, PF-06409577 was profiled in regulatory toxicology studies and was subsequently advanced to clinical trials to assess human pharmacokinetics and safety/ tolerability. |
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