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CAS号 | 1632118-69-4 | 货号 | BCP24972 |
中文名 | BAR501 | ||
英文名 | BAR501 | ||
中文别名 | |||
英文别名 | BAR-501; BAR 501; | ||
SMILES | C[C@H](CCCO)[C@H]1CC[C@@]2([H])[C@]3([H])[C@@H](O)[C@@H](CC)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C | ||
化学名称 | |||
分子式 | C26H46O3 | 分子量 | 406.64 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | BAR-501 is a selective GPBAR1 agonist devoid of any FXR agonistic activity. BAR501 effectively reduced hepatic perfusion pressure and counteracted the vasoconstriction activity of norepinephrine. BAR501 rescues from endothelial dysfunction in rodent models of portal hypertension by exerting genomic and non-genomic effects on CSE, eNOS and ET-1 in liver sinusoidal cells. |
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