缬更昔洛韦盐酸盐

参考资料仅供科学研究，不可用于个人用途。

货号：BCP08146CAS号：175865-59-5纯度：98%

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CAS号	175865-59-5	货号	BCP08146
中文名	缬更昔洛韦盐酸盐
英文名	Valganciclovir hydrochloride
中文别名
英文别名
SMILES
化学名称
分子式	C14H23ClN6O5	分子量	390.83
纯度	98%	配送	惯例下常温包邮
产品描述	in vitro: In cell culture model systems using Caco-2 cells for PEPT1 and SKPT cells for PEPT2, valganciclovir inhibited glycylsarcosine transport mediated by PEPT1 and PEPT2 with K(i) values (inhibition constant) of 1.68+/-0.30 and 0.043+/- 0.005 mM, respectively. The inhibition by valganciclovir was competitive in both cases . in vivo: 37 patients were enrolled; 19 patients received treatment with VGV and 18 patients received treatment with GCV. The VGV was not inferior in efficacy to GCV as pre-emptive therapy, with rates of viral clearance at 28 days of 89.5% and 83%, respectively (P-value for non-inferiority = 0.030). Toxicities were similar between the 2 arms. No patients developed CMV disease [2]. Patients being treated with an alemtuzumab-containing regimen received prophylaxis with either valaciclovir 500 mg orally daily orvalganciclovir 450 mg orally twice daily. None of the 20 patients randomized to valganciclovir experienced CMV reactivation (P = .004) .