PD0166285

参考资料仅供科学研究，不可用于个人用途。

货号：BCP20228CAS号：185039-89-8纯度：98%

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CAS号	185039-89-8	货号	BCP20228
中文名	PD0166285
英文名	PD0166285
中文别名
英文别名	PD-0166285;PD 0166285;
SMILES
化学名称
分子式	C26H27Cl2N5O2	分子量	512.43
纯度	98%	配送	惯例下常温包邮
产品描述	PD0166285 is identified to inhibit Wee1 activity at nanomolar concentrations. The inhibitor abrogates G2/M checkpoint inducing early cell division. At the cellular level, 0.5 μM PD0166285 dramatically inhibits irradiation-induced Cdc2 phosphorylation at the Tyr-15 and Thr-14 in seven of seven cancer cell lines tested. This G2 checkpoint abrogation by PD0166285 is demonstrated to kill cancer cells. PD0166285 does not inhibit Cdc2/cyclin B but inhibits Chk1 kinase at a much higher concentration (3433 nM). the treatment of cells with the inhibitor is related to microtubule stabilization and decrease in cyclin D transcription. Thus, PD0166285 may be a potentially useful anti-cancer therapy. PD0166285 at 0.5 μM concentration can inhibit Cdc2Y15 /T14 phosphorylation in all cell lines tested, regardless of their p53 status and pharmacological targeting of WEE1 by PD0166285 sensitizes U251-FM GBM tumors to IR in vivo.