Bomedemstat 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP45548CAS号：1990504-34-1纯度：98%

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CAS号	1990504-34-1	货号	BCP45548
关联产品	1990504-72-7（Bomedemstat ditosylate）
中文名	Bomedemstat
英文名	Bomedemstat
中文别名
英文别名	IMG-7289; IMG 7289; IMG7289;
SMILES	CN1CCN(CC1)C(=O)C(CCCNC2CC2C3=CC=C(C=C3)F)NC(=O)C4=CC=C(C=C4)N5C=CN=N5
化学名称
分子式	C28H34FN7O2	分子量	519.61
纯度	98%	配送	惯例下常温包邮
产品描述	Bomedemstat is an orally available, irreversible inhibitor of lysine-specific demethylase 1 (LSD1), with potential antineoplastic activity. Upon administration, bomedemstat binds to and inhibits LSD1, a demethylase that suppresses the expression of target genes by converting the di- and mono-methylated forms of lysine at position 4 of histone H3 (H3K4) to mono- and unmethylated H3K4. LSD1 inhibition enhances H3K4 methylation and increases the expression of tumor suppressor genes. In addition, LSD1 demethylates mono- or di-methylated H3K9 which increases gene expression of tumor promoting genes; thus, inhibition of LSD1 also promotes H3K9 methylation and decreases transcription of these genes. Altogether, this may lead to an inhibition of cell growth in LSD1-overexpressing tumor cells. LSD1, an enzyme belonging to the flavin adenine dinucleotide (FAD)-dependent amine oxidase family is overexpressed in certain tumor cells and plays a key role in the regulation of gene expression, tumor cell growth and survival.