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| CAS号 | 2097002-61-2 | 货号 | BCP20662 |
| 中文名 | LOXO-195 | ||
| 英文名 | LOXO-195 | ||
| 中文别名 | 赛利替尼; | ||
| 英文别名 | LOXO 195; LOXO195;Selitrectinib; | ||
| SMILES | CC1CCC2=NC=C(C=C2C3CCCN3C4=NC5=C(C=NN5C=C4)C(=O)N1)F | ||
| 化学名称 | |||
| 分子式 | C20H21FN6O | 分子量 | 380.43 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | LOXO-195 is a potent and selective TRK inhibitor capable of addressing potential mechanisms of acquired resistance that may emerge in patients receiving larotrectinib (LOXO-101) or multikinase inhibitors with anti-TRK activity. LOXO-195 demonstrated potent inhibition of TRK fusions, including critical acquired resistance mutations, in enzyme and cellular assays, with minimal activity against other kinases. In diverse TRK fusion mouse models, LOXO-195 inhibited phospho-ERK and caused dramatic tumor growth inhibition, superior to first generation TRK inhibitors, without significant toxicity. | ||
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