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| CAS号 | 2125956-82-1 | 货号 | BCP36149 |
| 中文名 | PXS-5153A dihydrochloride | ||
| 英文名 | PXS-5153A dihydrochloride | ||
| 中文别名 | |||
| 英文别名 | PXS-5153A 2HCl;PXS-5153A; PXS 5153A; PXS5153A; | ||
| SMILES | CC1=C(C2=C(N1CC(=CCN)F)C=CC=N2)C3=CC(=CC=C3)S(=O)(=O)N(C)C.Cl.Cl | ||
| 化学名称 | |||
| 分子式 | C20H25Cl2FN4O2S | 分子量 | 475.4 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | PXS-5153A is a novel mechanism based, fast-acting, dual LOXL2/LOXL3 inhibitor, which was used to interrogate the role of these enzymes in models of collagen crosslinking and fibrosis. PXS-5153A dose-dependently reduced LOXL2-mediated collagen oxidation and collagen crosslinking in vitro. In two liver fibrosis models, carbon tetrachloride or streptozotocin/high fat diet-induced, PXS-5153A reduced disease severity and improved liver function by diminishing collagen content and collagen crosslinks. In myocardial infarction, PXS-5153A improved cardiac output. | ||
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