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| CAS号 | 2172870-89-0 | 货号 | BCP47002 |
| 中文名 | Paltusotine | ||
| 英文名 | Paltusotine | ||
| 中文别名 | |||
| 英文别名 | CRN00808; CRN-00808; CRN 00808; | ||
| SMILES | C1CN(CCC1N)C2=C3C=C(C=CC3=NC=C2C4=CC(=CC(=C4)F)F)C5=CC=CC(=C5O)C#N | ||
| 化学名称 | |||
| 分子式 | C27H22F2N4O | 分子量 | 456.49 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | Paltusotine is an orally bioavailable, nonpeptide somatostatin receptor type 2 (SST2; SSTR2) agonist, with potential growth hormone (GH) secretion-inhibiting and antineoplastic activities. Upon oral administration, paltusotine targets, binds to and activates SSTR2, which leads to an inhibition in the secretion of human growth hormone (hGH) in the pituitary gland and results in decreased production of insulin-like growth factor (IGF-1). This may inhibit IGF-1-mediated cell signaling pathways, and lead to apoptosis. SSTR2 is overexpressed by some neuroendocrine tumor cells, and GH is over-produced in the pituitary gland in acromegaly. | ||
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