Casopitant 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP18249CAS号：414910-27-3纯度：98%

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CAS号	414910-27-3	货号	BCP18249
中文名	Casopitant
英文名	Casopitant
中文别名
英文别名	GW679769; GW 679769; GW-679769;
SMILES	CC1=C(C=CC(=C1)F)C2CC(CCN2C(=O)N(C)C(C)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)N4CCN(CC4)C(=O)C
化学名称
分子式	C30H35F7N4O2	分子量	616.62
纯度	98%	配送	惯例下常温包邮
产品描述	Casopitant is a centrally-acting neurokinin 1 (NK1) receptor antagonist with antidepressant and antiemetic activities. Casopitant competitively binds to and blocks the activity of the NK-receptor, thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in antiemetic effects. SP is found in neurons of vagal afferent fibers innervating the brain-stem nucleus tractus solitarii and the area postrema, which contains the chemoreceptor trigger zone (CTZ), and may be elevated in response to chemotherapy. The NK-receptor is a G-protein receptor coupled to the inositol phosphate signal-transduction pathway and is found in both the nucleus tractus solitarii and the area postrema.