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CAS号 | 50-55-5 | 货号 | BCP02074 |
中文名 | 利血平 | ||
英文名 | Reserpine | ||
中文别名 | |||
英文别名 | Serpalan; | ||
SMILES | |||
化学名称 | |||
分子式 | C33H40N2O9 | 分子量 | 608.68 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Reserpine (Lannett's Serpalan) is an indole alkaloid antipsychotic and antihypertensive drug that has been used for the control of high blood pressure and for the relief of psychotic symptoms, although because of the development of better drugs for these purposes and because of its numerous side-effects, it is rarely used today. The antihypertensive actions of reserpine are a result of its ability to deplete catecholamines (among other monoamine neurotransmitters) from peripheral sympathetic nerve endings. These substances are normally involved in controlling heart rate, force of cardiac contraction and peripheral vascular resistance. Reserpine irreversibly blocks the vesicular monoamine transporter (VMAT). This normally transports free intracellular norepinephrine, serotonin, and dopamine in the presynaptic nerve terminal into presynaptic vesicles for subsequent release into the synaptic cleft ("exocytosis"). Unprotected neurotransmitters are metabolized by MAO (as well as by COMT) in |
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