Palosuran

参考资料仅供科学研究，不可用于个人用途。

货号：BCP15786CAS号：540769-28-6纯度：98%

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CAS号	540769-28-6	货号	BCP15786
中文名	Palosuran
英文名	Palosuran
中文别名
英文别名	ACT-058362;ACT 058362;ACT058362;
SMILES
化学名称
分子式	C25H30N4O2	分子量	418.53
纯度	98%	配送	惯例下常温包邮
产品描述	Palosuran inhibited 125I-U-II binding to human UT receptors in membrane preparations from CHO cells carrying the human UT receptors almost as potently as cold U-II, with an IC50 of 3.6 ± 0.2 nM. On cells, the inhibitory binding potency of palosuran against human UT receptor was lower than on membranes (IC50 = 46.2 ± 13 nM on TE 671 cells and 86 ± 30 nM on recombinant CHO cells). Compared with the human UT receptor, the binding inhibitory potency of palosuran against the rat UT receptor was lower in membrane preparation (400-fold), as well as in cells (>120-fold) . in vivo: Long-term treatment of streptozotocin-induced diabetic rats with palosuran improved survival, increased insulin, and slowed the increase in glycemia, glycosylated hemoglobin, and serum lipids. Furthermore, palosuran increased renal blood flow and delayed the development of proteinuria and renal damage . Palosuran was rapidly absorbed with maximum plasma concentrations at 1 hour after drug administration. The accumula