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Amitriptyline hydrochloride 结构式

盐酸阿米替林

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货号 :BCP31573CAS号 :549-18-8纯度:98%
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  • 基本信息与产品描述
CAS号 549-18-8 货号 BCP31573
中文名 盐酸阿米替林
英文名 Amitriptyline hydrochloride
中文别名 阿米替林盐酸盐;
英文别名 Amitriptyline HCl;Nortriptyline Impurity F;
SMILES CN(C)CCC=C1C2=CC=CC=C2CCC3=CC=CC=C31.Cl
化学名称
分子式 C20H23N.HCl 分子量 313.87
纯度 98% 配送 惯例下常温包邮
产品描述 Amitriptyline Hydrochloride is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities. Amitriptyline inhibits the re-uptake of norepinephrine and serotonin by the presynaptic neuronal membrane in the central nervous system (CNS), thereby increasing the synaptic concentration of norepinephrine and serotonin. Due to constant stimulation to these receptors, amitriptyline may produce a downregulation of adrenergic and serotonin receptors, which may contribute to the antidepressant activity. In the CNS the antinociceptive activity of this agent may involve high affinity binding to and inhibition of N-methyl-D-aspartate (NMDA) receptors and/or the enhancement of the action of serotonin at the spinal terminals of an opioid-mediated intrinsic analgesia system.
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