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| CAS号 | 551909-15-0 | 货号 | BCP44866 |
| 中文名 | RTICBM-189 | ||
| 英文名 | RTICBM-189 | ||
| 中文别名 | |||
| 英文别名 | RTICBM 189; RTICBM189; | ||
| SMILES | O=C(NCCC1=CC=CC(Cl)=C1)NC2=CC=C(Cl)C=C2 | ||
| 化学名称 | |||
| 分子式 | C15H14Cl2N2O | 分子量 | 309.19 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | RTICBM-189 is a Urea derivative and a CB1 allosteric modulator. RTICBM-189 showed no activity at >50 protein targets and excellent brain permeation but relatively low metabolic stability in rat liver microsomes. Pharmacokinetic studies in rats confirmed the excellent brain exposure of 31 with a brain/plasma ratio Kp of 2.0. Importantly, intraperitoneal administration of RTICBM-189 significantly and selectively attenuated the reinstatement of the cocaine-seeking behavior in rats without affecting locomotion. | ||
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