Alvelestat

参考资料仅供科学研究，不可用于个人用途。

货号：BCP07945CAS号：848141-11-7纯度：98%

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CAS号	848141-11-7	货号	BCP07945
中文名	Alvelestat
英文名	Alvelestat
中文别名
英文别名	AZD9668;AZD-9668;AZD 9668;
SMILES
化学名称
分子式	C25H22F3N5O4S	分子量	545.53
纯度	98%	配送	惯例下常温包邮
产品描述	in vitro: AZD9668 had a high binding affinity for human NE (KD = 9.5 nM) and potently inhibited NE activity. The calculated pIC50 (IC50) and Ki values for AZD9668 for human NE were 7.9 (12 nM) and 4.9 nM, respectively. In contrast to earlier NE inhibitors, the interaction between AZD9668 and NE was rapidly reversible. AZD9668 was also highly selective for NE over other neutrophil-derived serine proteases. In cell-based assays, AZD9668 inhibited plasma NE activity in zymosan-stimulated whole blood. In isolated human polymorphonuclear cells, AZD9668 inhibited NE activity on the surface of stimulated cells and in the supernatant of primed, stimulated cells.AZD9668 showed good crossover potency to NE from other species. in vivo: Six hundred and fifteen patients were randomised: placebo (302), AZD9668 60 mg bid (313). AZD9668 showed no effect on lung function: change in mean pre-bronchodilator FEV1 versus placebo was 0.01L (95% confidence interval: -0.03, 0.05; p=0.533). AZD9668 did not sig