TAME

参考资料仅供科学研究，不可用于个人用途。

货号：BCP02395CAS号：901-47-3纯度：98%

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CAS号	901-47-3	货号	BCP02395
中文名	TAME
英文名	TAME
中文别名	N-[(4-甲基苯基)磺酰基]-L-精氨酸甲酯;
英文别名
SMILES
化学名称
分子式	C14H22N4O4S	分子量	342.41
纯度	98%	配送	惯例下常温包邮
产品描述	TAME inhibits cyclin proteolysis in mitotic Xenopus egg extract with IC50 of 12 μM. TAME at concentration of 1-200 μM arrests interphase extract treated with recombinant cyclin B1/Cdc2 complex in mitosis, with stable cyclin B1 and phosphorylated Cdc27. TAME at concentration of 200 μM dramaticly inhibits the ubiquitin ligase activity of the Anaphase-Promoting Complex (APC), accompanied by reduced binding of Cdh1 to APC. TAME addition to interphase extract reduces Cdc20 association with the APC in a dose-dependent manner partly by binding directly to APC, and the contribution motif is the C-terminal isoleucine-arginine (IR) tail on APC. TAME is hydrolysed by trypsin with Km of 0.328 mM. TAME accelerates the ATP hydrolysis process about 12-fold. TAME interacts with β and γ phosphate and the adenine ring of ATP by the guanidinium group and the aromatic ring. TAME at concentration of 50 mM inhibits nutrient-induced germination and pressure-induced germination at 600 MPa in Bacillus subtilis