氟替卡松新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP31287CAS号：90566-53-3纯度：98%

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CAS号	90566-53-3	货号	BCP31287
中文名	氟替卡松
英文名	Fluticasone
中文别名
英文别名	Fluticasonum;
SMILES	CC1CC2C3CC(C4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)SCF)O)C)O)F)C)F
化学名称
分子式	C22H27F3O4S	分子量	444.51
纯度	98%	配送	惯例下常温包邮
产品描述	Fluticasone is a synthetic trifluorinated glucocorticoid receptor agonist with antiallergic, antiinflammatory and antipruritic effects. Fluticasone binds and activates glucocorticoid receptor, resulting in the activation of lipocortin. Lipocortin, in turn, inhibits cytosolic phospholipase A2, which triggers a cascade of reactions involved in the synthesis of inflammatory mediators, such as prostaglandins and leukotrienes. Secondly, mitogen-activated protein kinase (MAPK) phosphatase 1 is induced, thereby leads to dephosphorylation and inactivation of Jun N-terminal kinase directly inhibiting c-Jun mediated transcription. Finally, transcriptional activity of nuclear factor (NF)-kappa-B is blocked, thereby inhibits the transcription of cyclooxygenase 2, which is essential for prostaglandin production.

氟替卡松 新