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| CAS号 | 929901-49-5 | 货号 | BCP28067 |
| 中文名 | Guadecitabine | ||
| 英文名 | Guadecitabine | ||
| 中文别名 | |||
| 英文别名 | SGI110; SGI-110; SGI 110; S110; | ||
| SMILES | C1C(C(OC1N2C=NC3=C2NC(=NC3=O)N)COP(=O)(O)OC4CC(OC4CO)N5C=NC(=NC5=O)N)O | ||
| 化学名称 | |||
| 分子式 | C18H24N9O10P | 分子量 | 557.41 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | Guadecitabine, aslo known as SGI-110, is a dinucleotide antimetabolite of a decitabine linked via phosphodiester bond to a guanosine, with potential antineoplastic activity. Following metabolic activation by phosphorylation and incorporation into DNA, SGI-110 inhibits DNA methyltransferase, thereby causing genome-wide and non-specific hypomethylation and inducing cell cycle arrest at S-phase. This agent is resistant to cytidine deaminase, hence may result in gradual release of decitabine both extra- and intracellularly, leading to more prolonged exposures to decitabine. | ||
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