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| CAS号 | RMC-5127 | 货号 | BCP49725 |
| 中文名 | RMC-5127 | ||
| 英文名 | RMC-5127 | ||
| 中文别名 | |||
| 英文别名 | RMC5127;RMC 5127; | ||
| SMILES | |||
| 化学名称 | |||
| 分子式 | C57H75N9O9S | 分子量 | 1062.33 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | RMC-5127 is an orally active and brain-penetrant mutant-selective tri-complex RASG12V inhibitor. RMC-5127 non-covalently binds to cyclophilin A (CypA), forming a binary complex that engages RASG12V(ON) to form a high-affinity tri-complex, sterically inhibiting RAS binding . RMC-5127 inhibits the RAS pathway in KRASG12V mutant cancer cells, reducing cell proliferation and inducing apoptosis. RMC-5127 is promising for research of cancers with RAS mutations, such as non-small cell lung cancer. | ||
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