AZD8055

参考资料仅供科学研究，不可用于个人用途。

货号：BCP02171CAS号：1009298-09-2纯度：98%

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CAS号	1009298-09-2	货号	BCP02171
中文名	AZD8055
英文名	AZD8055
中文别名
英文别名	AZD-8055;AZD 8055;CCG-168;CCG168;CCG 168;
SMILES
化学名称
分子式	C25H31N5O4	分子量	465.56
纯度	98%	配送	惯例下常温包邮
产品描述	AZD8055 shows low activity (～1,000-fold) against all PI3K isoforms (α, β, γ, δ) and other members of the PI3K-like kinase family (ATM and DNA-PK). AZD8055 inhibits the phosphorylation of mTORC1 (p70S6K and 4E-BP1) as well as phosphorylation of the mTORC2 (Akt) and downstream proteins. The rapamycin-resistant T37/46 phosphorylation sites on 4E-BP1 can be fully inhibited by AZD8055, resulting in significant inhibition of cap-dependent translation. AZD8055 potently inhibits proliferation in U87MG, A549 and H838 cells with IC50 of 53, 50 and 20 nM, respectively. AZD8055 also induces autophagy and increased LC3-II levels in H838 and A549 cells.AZD8055 decreases AML blast cell proliferation and cell cycle progression, reduces the clonogenic growth of leukemic progenitors and induces caspase-dependent apoptosis in leukemic cells but not in normal immature CD34+ cells. AZD8055 indicates inhibitory against the pediatric preclinical testing program (PPTP) cell lines with IC50 of 24.7?nM and indu