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CAS号 | 1219737-12-8 | 货号 | BCP29075 |
中文名 | MK-3903 | ||
英文名 | MK-3903 | ||
中文别名 | |||
英文别名 | MK 3903; MK3903; | ||
SMILES | |||
化学名称 | |||
分子式 | C27H19ClN2O3 | 分子量 | 454.91 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | MK-3903 is a potent and selective AMPK activator (EC50 = 8 nM). MK-3903 exhibited robust target engagement in mouse liver following oral dosing, leading to improved lipid metabolism and insulin sensitization in mice. Chronic oral administration of MK-3903 robustly increased ACC phosphorylation in liver with more modest effects in skeletal muscle. Treatment of various mouse models with MK-3903 resulted in expected alterations in lipid metabolism and improvements in a measure of insulin sensitization. |
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