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| CAS号 | 1379545-95-5 | 货号 | BCP19488 |
| 中文名 | M2698 | ||
| 英文名 | M2698 | ||
| 中文别名 | |||
| 英文别名 | M-2698;M 2698; MSC-2363318A; MSC 2363318A; MSC2363318A; | ||
| SMILES | O=C(C1=CC=CC2=C(N[C@@H](C3=CC=C(Cl)C(C(F)(F)F)=C3)CN4CCC4)N=CN=C12)N | ||
| 化学名称 | |||
| 分子式 | C21H19ClF3N5O | 分子量 | 449.86 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | M2698, also known as MSC-2363318A, is a potent dual-inhibitor of p70S6K and Akt that affects tumor growth in mouse models of cancer and crosses the blood-brain barrier. M2698 was highly potent in vitro (IC50 1 nM for p70S6K, Akt1 and Akt3 inhibition; IC50 17 nM for pGSK3β indirect inhibition) and in vivo (IC50 15 nM for pS6 indirect inhibition), and relatively selective (only 6/264 kinases had an IC50 within 10-fold of p70S6K). | ||
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