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| CAS号 | 1445179-97-4 | 货号 | BCP46470 |
| 中文名 | 布立匹肽 | ||
| 英文名 | Brimapitide | ||
| 中文别名 | |||
| 英文别名 | D-JNKI-1;L-JNKi1; | ||
| SMILES | |||
| 化学名称 | |||
| 分子式 | C164H286N66O40 | 分子量 | 3822.4 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | Brimapitide is a protease resistant, potent inhibitor specific for JNK (JNK1, JNK2 and JNK3). L-JNKi 1 does not directly affect kinase activity e.g. by competing with the ATP-binding site of the protein kinase, rather L-JNKi1 inhibits the interaction between JNK and its substrate, resulting in a JNK K.O. phenotype. In contrast to pure diffusion they are actively transported into cells, where they remain until their proteolytic degradation. The c-Jun N-terminal kinases (JNK1, 2, 3), members of the mitogen-activated protein kinase (MAPK) superfamily, are activated by a wide variety of extracellular stimuli such as inflammatory cytokines, heat shock and ischemia. | ||
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