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| CAS号 | 1446502-11-9 | 货号 | BCP16041 |
| 中文名 | 恩西地平 | ||
| 英文名 | Enasidenib | ||
| 中文别名 | |||
| 英文别名 | AG-221; AG 221; AG221; CC-90007; CC 90007; CC90007; | ||
| SMILES | CC(O)(C)CNC1=NC(C2=NC(C(F)(F)F)=CC=C2)=NC(NC3=CC(C(F)(F)F)=NC=C3)=N1 | ||
| 化学名称 | |||
| 分子式 | C19H17F6N7O | 分子量 | 473.37 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | Enasidenib, aslo known as AG-221 and CC-90007, is a potent and selective IDH2 inhibitor with potential anticancer activity (IDH2 = Isocitrate dehydrogenase 2). The mutations of IDH2 present in certain cancer cells result in a new ability of the enzyme to catalyze the NAPH-dependent reduction of α-ketoglutarate to R(-)-2-hydroxyglutarate (2HG). The production of 2HG is believed to contribute to the formation and progression of cancer . The inhibition of mutant IDH2 and its neoactivity is therefore a potential therapeutic treatment for cancer. | ||
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