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CAS号 | 1628805-46-8 | 货号 | BCP30411 |
中文名 | IDH-305 | ||
英文名 | IDH-305 | ||
中文别名 | |||
英文别名 | IDH 305; IDH305; | ||
SMILES | CC1=CC(=NC=C1C2=CC(=NC=C2)C(F)(F)F)C(C)NC3=NC=CC(=N3)N4C(COC4=O)C(C)F | ||
化学名称 | |||
分子式 | C23H22F4N6O2 | 分子量 | 490.45 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | IDH305 is an inhibitor of the citric acid cycle enzyme isocitrate dehydrogenase [NADP] cytoplasmic (isocitrate dehydrogenase 1; IDH1) with mutations at residue R132 (IDH1(R132)), with potential antineoplastic activity. Upon administration, IDH305 specifically inhibits IDH1(R132) mutant forms in the cytoplasm, which inhibits the formation of the oncometabolite 2-hydroxyglutarate (2HG). This may lead to both an induction of cellular differentiation and an inhibition of cellular proliferation in IDH1(R132)-expressing tumor cells. |
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