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IDH-305

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货号 :BCP30411CAS号 :1628805-46-8纯度:98%
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  • 基本信息与产品描述
CAS号 1628805-46-8 货号 BCP30411
中文名 IDH-305
英文名 IDH-305
中文别名
英文别名 IDH 305; IDH305;
SMILES CC1=CC(=NC=C1C2=CC(=NC=C2)C(F)(F)F)C(C)NC3=NC=CC(=N3)N4C(COC4=O)C(C)F
化学名称
分子式 C23H22F4N6O2 分子量 490.45
纯度 98% 配送 惯例下常温包邮
产品描述 IDH305 is an inhibitor of the citric acid cycle enzyme isocitrate dehydrogenase [NADP] cytoplasmic (isocitrate dehydrogenase 1; IDH1) with mutations at residue R132 (IDH1(R132)), with potential antineoplastic activity. Upon administration, IDH305 specifically inhibits IDH1(R132) mutant forms in the cytoplasm, which inhibits the formation of the oncometabolite 2-hydroxyglutarate (2HG). This may lead to both an induction of cellular differentiation and an inhibition of cellular proliferation in IDH1(R132)-expressing tumor cells.
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