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K145 hydrochloride 结构式

K145 hydrochloride

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货号 :BCP43089CAS号 :1449240-68-9纯度:98%
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  • 基本信息与产品描述
CAS号 1449240-68-9 货号 BCP43089
中文名 K145 hydrochloride
英文名 K145 hydrochloride
中文别名
英文别名 K145 HCl; K 145 HCl; K-145 HCl; K-145 hydrochloride;
SMILES CCCCOC1=CC=C(C=C1)CCC=C2C(=O)N(C(=O)S2)CCN.Cl
化学名称
分子式 C18H25ClN2O3S 分子量 384.92
纯度 98% 配送 惯例下常温包邮
产品描述 K145 is a selective sphingosine kinase-2 (SphK2) inhibitor and anticancer agent. K145 inhibited the activity of SphK2 in a dose-dependent manner with an IC50 of 4.30±0.06 µM. K145 also exhibited inhibitory effects on the growth of U937 cells as well as apoptotic effects in U937 cells. K145 exhibits comparable in vivo anti-tumor activity to tamibarotene, while concomitantly exhibiting less toxicity in this U937 xenograft cancer model.
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