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CAS号 | 1449240-68-9 | 货号 | BCP43089 |
中文名 | K145 hydrochloride | ||
英文名 | K145 hydrochloride | ||
中文别名 | |||
英文别名 | K145 HCl; K 145 HCl; K-145 HCl; K-145 hydrochloride; | ||
SMILES | CCCCOC1=CC=C(C=C1)CCC=C2C(=O)N(C(=O)S2)CCN.Cl | ||
化学名称 | |||
分子式 | C18H25ClN2O3S | 分子量 | 384.92 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | K145 is a selective sphingosine kinase-2 (SphK2) inhibitor and anticancer agent. K145 inhibited the activity of SphK2 in a dose-dependent manner with an IC50 of 4.30±0.06 µM. K145 also exhibited inhibitory effects on the growth of U937 cells as well as apoptotic effects in U937 cells. K145 exhibits comparable in vivo anti-tumor activity to tamibarotene, while concomitantly exhibiting less toxicity in this U937 xenograft cancer model. |
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