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| CAS号 | 1807861-48-8 | 货号 | BCP44033 |
| 中文名 | ONC212 | ||
| 英文名 | ONC212 | ||
| 中文别名 | |||
| 英文别名 | ONC-212; ONC 212; | ||
| SMILES | C1CN(CC2=C1N3CCN=C3N(C2=O)CC4=CC=C(C=C4)C(F)(F)F)CC5=CC=CC=C5 | ||
| 化学名称 | |||
| 分子式 | C24H23F3N4O | 分子量 | 440.46 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | ONC212 is a fluorinated-ONC201 analogue, shows preclinical efficacy in melanoma and hepatocellular-cancer models. ONC212 is active in pancreatic cancer as single agent or in combination with 5-fluorouracil, irinotecan, oxaliplatin or RTK inhibitor crizotinib. ONC212 exhibited rapid kinetics of activity. ONC212 was further tested in >1000 human cancer cell lines in vitro and evaluated for safety and anti-tumor efficacy in vivo. ONC212 exhibited broad-spectrum efficacy at nanomolar concentrations across solid tumors and hematological malignancies. | ||
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