瑞舒伐他汀钙

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货号：BCP04131CAS号：147098-20-2纯度：98%

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CAS号	147098-20-2	货号	BCP04131
中文名	瑞舒伐他汀钙
英文名	Rosuvastatin Calcium
中文别名	罗舒伐他汀钙;超级他汀钙;
英文别名	S-4522; S 4522; S4522; ZD 4522; ZD-4522; ZD4522; ZD 4522 calcium salt;Rosuvastatin hemicalcium; ZD 4522 Calcium;CRESTOR;Rosuvastatin Calcium Salt;
SMILES
化学名称
分子式	2(C22H27FN3O6S).Ca	分子量	1001.14
纯度	98%	配送	惯例下常温包邮
产品描述	Rosuvastatin is relatively hydrophilic and is highly selective for hepatic cells; its uptake is mediated by the liver-specific organic anion transporter OATP-C. Rosuvastatin is a high-affinity substrate for OATP-C with apparent association constant of 8.5 μM.Rosuvastatin inhibits cholesterol biosynthesis in rat liver isolated hepatocytes with IC50 of 1.12 nM. Rosuvastatin causes approximately 10 times greater increase of mRNA of LDL receptors than pravastatin. Rosuvastatin (100 μM) decreases the extent of U937 adhesion to TNF-α-stimulated HUVEC. Rosuvastatin inhibits the expressions of ICAM-1, MCP-1, IL-8, IL-6, and COX-2 mRNA and protein levels through inhibition of c-Jun N-terminal kinase and nuclear factor-kB in endothelial cells.