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CAS号 | 1610759-22-2 | 货号 | BCP31204 |
中文名 | CFI-402257 | ||
英文名 | CFI-402257 | ||
中文别名 | |||
英文别名 | CFI 402257; CFI402257; | ||
SMILES | CC1=C(C=CC(=C1)C2=C3N=C(C=C(N3N=C2)NCC4CC(C4)(C)O)OC5=CN=CC=C5)C(=O)NC6CC6 | ||
化学名称 | |||
分子式 | C28H30N6O3 | 分子量 | 498.59 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | CFI-402257 is a highly potent and selective TTK (threonine tyrosine kinase) Inhibitor ((TTK Ki = 0.1 nM) with potential anticancer activity. TTK is an essential chromosomal regulator and is overexpressed in aneuploid tumors. High TTK levels correlate with a high tumor grade11 and poor patient outcomes. TTK inhibition are associated with a disabled mitotic checkpoint, resulting in chromosome segregation errors, aneuploidy, and cell death. |
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