富马酸卢帕他定

参考资料仅供科学研究，不可用于个人用途。

货号：BCP05230CAS号：182349-12-8纯度：98%

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CAS号	182349-12-8	货号	BCP05230
关联产品	158876-82-5（卢帕他定）
中文名	富马酸卢帕他定
英文名	Rupatadine fumarate
中文别名
英文别名	UR-12592 Fumarate;UR12592 Fumarate;UR 12592 Fumarate; Rupafin; Alergoliber; Rinialer; Pafinur; Rupax; Ralif;
SMILES
化学名称
分子式	C26H26ClN3.C4H4O4	分子量	532.03
纯度	98%	配送	惯例下常温包邮
产品描述	Rupatadine inhibits both platelet-activating factor (PAF) and histamine (H1) effects through its interaction with specific receptors. Rupatadine competitively inhibits histamine-induced guinea pig ileum contraction (pA2 = 9.29 ± 0.06) without affecting contraction induced by ACh, serotonin or leukotriene D4(LTD4). It also competitively inhibits PAF-induced platelet aggregation in washed rabbit platelets (WRP) (pA2= 6.68 ± 0.08) and in human platelet-rich plasma (HPRP) (IC50 = 0.68 μM), while not affecting ADP- or arachidonic acid-induced platelet aggregation. [1] In another study, it is reported rupatadine and loratadine shows similar inhibitory effect on histamine and TNF-α release, whereas SR-27417A only exhibits inhibitory effect against TNF-α.