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| CAS号 | 524-12-9 | 货号 | BCP19859 |
| 中文名 | 蟛蜞菊内酯 | ||
| 英文名 | Wedelolactone | ||
| 中文别名 | |||
| 英文别名 | |||
| SMILES | |||
| 化学名称 | |||
| 分子式 | C16H10O7 | 分子量 | 314.25 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | Wedelolactone is a potent Î2-arrestin-biased G protein-coupled receptor-35 (GPR35) agonist, GPR35 has been shown to be a target of the asthma drugs cromolyn disodium and nedocromil sodium. Wedelolactone has anti-inflammatory, growth inhibitory, anti-cancer, anti-fibrotic, and pro-apoptotic effects. Wedelolactone stimulates ER genomic and non-genomic signalling pathways; it can significantly inhibit the activation of LX-2 cells, the underlying mechanisms of which included inducing Bcl-2 family involved apoptosis, up-regulating phosphorylated status of ERK and JNK expressions, and inhibiting NF-κB mediated activity. | ||
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