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CAS号 | 19542-67-7 | 货号 | BCP06798 |
中文名 | Bay 11-7821 | ||
英文名 | Bay 11-7821 | ||
中文别名 | |||
英文别名 | BAY11-7082; BAY-11-7082; BAY 117082; BAY117082; BAY-11708; | ||
SMILES | |||
化学名称 | |||
分子式 | C10H9NO2S | 分子量 | 207.25 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | BAY 11-7082 is an inhibitor of κB kinase (IKK) that has pharmacological activities that include anticancer, neuroprotective, and anti-inflammatory effects. BAY 11-7082 strongly suppressed the production of nitric oxide, prostaglandin E(2), and tumor necrosis factor-α and reduced the translocation of p65, major subunit of nuclear factor-κB, and its upstream signaling events such as phosphorylation of IκBα, IKK, and Akt. In addition. Bay 11-7082 induces cell death independent from inhibition of activation of NFκB transcription factors.BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system. Bay 11-7082 induces cell death independent from inhibition of activation of NFκB transcription factors. |
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