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Pactimibe sulfate 结构式

帕替麦布硫酸盐

参考资料 仅供科学研究,不可用于个人用途。
货号 :BCP45168CAS号 :608510-47-0纯度:98%
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  • 基本信息与产品描述
CAS号 608510-47-0 货号 BCP45168
关联产品 189198-30-9(帕替麦布)
中文名 帕替麦布硫酸盐
英文名 Pactimibe sulfate
中文别名
英文别名 CS-505 sulfate; CS505 sulfate; CS 505 sulfate;
SMILES CCCCCCCCN1CCC2=C(C(=C(C(=C21)NC(=O)C(C)(C)C)C)CC(=O)O)C.CCCCCCCCN1CCC2=C(C(=C(C(=C21)NC(=O)C(C)(C)C)C)CC(=O)O)C.OS(=O)(=O)O
化学名称
分子式 C50H82N4O10S 分子量 931.28
纯度 98% 配送 惯例下常温包邮
产品描述 Pactimibe, also known as CS-505, is a ACAT inhibitor. Pactimibe stabilizes atherosclerotic plaque through macrophage acyl-CoA:cholesterol acyltransferase inhibition in WHHL rabbits. Pactimibe reduces and stabilizes atherosclerotic lesions by cholesterol-lowering and direct effects in apolipoprotein E-deficient mice. Pactimibe inhibits cholesterol absorption from the intestine, reduces cholesteryl ester formation in the liver, and enhances its elimination from the body. The Triton WR-1339 experiment showed that pactimibe inhibited secretion of very low density lipoprotein cholesterol from the liver. These results suggest that pactimibe is likely to have multiple mechanisms of action responsible for its effectiveness in reducing serum cholesterol.
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