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CAS号 | 124832-26-4 | 货号 | BCP28415 |
中文名 | 伐昔洛韦 | ||
英文名 | Valacyclovir | ||
中文别名 | |||
英文别名 | Valaciclovir;Val-ACV; Valtrex; Zelitrex; | ||
SMILES | O=C(N1)C2=C(N=C1N)N(COCCOC([C@@H](N)C(C)C)=O)C=N2 | ||
化学名称 | |||
分子式 | C13H20N6O4 | 分子量 | 324.34 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Valacyclovir, also known as valacyclovir, is an antiviral drug used in the management of herpes simplex, herpes zoster (shingles), and herpes B. It is a prodrug, being converted in vivo to aciclovir. Valaciclovir has been available as a generic drug in the U.S. since November 25, 2009. Valaciclovir is a prodrug, an esterified version of aciclovir that has greater oral bioavailability (about 55%) than aciclovir (10–20%). It is converted by esterases to the active drug aciclovir, as well as the amino acid valine, via hepatic first-pass metabolism. Aciclovir is selectively converted into a monophosphate form by viral thymidine kinase, which is far more effective (3000 times) in phosphorylation of aciclovir than cellular thymidine kinase. |
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