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Valacyclovir 结构式

伐昔洛韦

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货号 :BCP28415CAS号 :124832-26-4纯度:98%
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  • 基本信息与产品描述
CAS号 124832-26-4 货号 BCP28415
中文名 伐昔洛韦
英文名 Valacyclovir
中文别名
英文别名 Valaciclovir;Val-ACV; Valtrex; Zelitrex;
SMILES O=C(N1)C2=C(N=C1N)N(COCCOC([C@@H](N)C(C)C)=O)C=N2
化学名称
分子式 C13H20N6O4 分子量 324.34
纯度 98% 配送 惯例下常温包邮
产品描述 Valacyclovir, also known as valacyclovir, is an antiviral drug used in the management of herpes simplex, herpes zoster (shingles), and herpes B. It is a prodrug, being converted in vivo to aciclovir. Valaciclovir has been available as a generic drug in the U.S. since November 25, 2009. Valaciclovir is a prodrug, an esterified version of aciclovir that has greater oral bioavailability (about 55%) than aciclovir (10–20%). It is converted by esterases to the active drug aciclovir, as well as the amino acid valine, via hepatic first-pass metabolism. Aciclovir is selectively converted into a monophosphate form by viral thymidine kinase, which is far more effective (3000 times) in phosphorylation of aciclovir than cellular thymidine kinase.
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