Silmitasertib sodium 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP38774CAS号：1309357-15-0纯度：98%

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CAS号	1309357-15-0	货号	BCP38774
中文名	Silmitasertib sodium
英文名	Silmitasertib sodium
中文别名
英文别名	Silmitasertib sodium salt;CX-4945 sodium salt;CX4945 Sodium;
SMILES	C1=CC(=CC(=C1)Cl)NC2=NC3=C(C=CC(=C3)C(=O)[O-])C4=C2C=CN=C4.[Na+]
化学名称
分子式	C19H11ClN3NaO2	分子量	371.75
纯度	98%	配送	惯例下常温包邮
产品描述	Silmitasertib Sodium is the sodium salt of silmitasertib, an orally bioavailable small-molecule inhibitor of CK2 with potential antineoplastic activity. Silmitasertib selectively binds to and inhibits the enzyme casein kinase II (CK2), which may lead to an inhibition of cellular proliferation. CK2, a protein kinase often overexpressed in a variety of cancer cell types, appears to be correlated with malignant transformation, tumor growth and survival. CK2 regulates a diverse array of pro-survival cellular processes including epidermal growth factor receptor (EGFR) signaling, PI3K/AKT/mTOR signaling, hedgehog (Hh) signaling, Hsp90 machinery, hypoxia, and interleukin (IL)-6 expression. CK2 also regulates the activity of XRCC1 and MDC1, two mediator/adaptor proteins that are essential for DNA repair.