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D4476 结构式

D4476

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货号 ：BCP09776CAS号 ：301836-43-1纯度：98%
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  • 基本信息与产品描述
CAS号 301836-43-1 货号 BCP09776
中文名 D4476
英文名 D4476
中文别名
英文别名 Casein Kinase I Inhibitor;D 4476;D-4476;
SMILES
化学名称
分子式 C23H18N4O3 分子量 398.41
纯度 98% 配送 惯例下常温包邮
产品描述 D4476 is a less effective inhibitor of PKD1 (IC50 = 9.1 μM) and p38α MAPK (IC50 = 5.8 μM), and only weakly affects the activities of a panel of kinases tested, including Akt1 (PKB), SGK and GSK-3b. D4476 may either inhibit or foster apoptosis. D4476 inhibits nuclear export of eIF6 and results in nuclear accumulation of eIF6. In HeLa cells D4476 has been used to inhibit CK-1 phosphorylation of RhoB but not RhoA or RhoC activating RhoB dependent actin fiber formation. D4476 has been observed to block the Wnt-3a-induced phosphorylation and shift in electrophoretic migration of Dvl-1(dishevelled, Dvl).
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