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| CAS号 | 1334237-71-6 | 货号 | BCP25093 |
| 中文名 | 维考西肽盐酸盐 | ||
| 英文名 | Etelcalcetide HCl | ||
| 中文别名 | |||
| 英文别名 | AMG 416; AMG-416; AMG416; KAI-4169; KAI4169; KAI 4169 HCl; | ||
| SMILES | |||
| 化学名称 | |||
| 分子式 | C38H74ClN21O10S2 | 分子量 | 1084.72 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | Etelcalcetide is a calcimimetic and calcium-sensing receptor (CaSR) agonist composed of a synthetic peptide comprised of seven D-amino acids that can be used to treat secondary hyperparathyroidism (sHPT) in hemodialysis patients with chronic kidney disease (CKD). Upon intravenous administration, etelcalcetide mimics calcium and allosterically binds to and activates the CaSR expressed by the parathyroid gland. This suppresses the synthesis and secretion of parathyroid hormone (PTH), thereby reducing PTH levels and lowering serum calcium and phosphorus levels. Elevated PTH is often observed in patients with CKD and is associated with dysregulated calcium-phosphate homeostasis. | ||
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