NPS-2143 hydrochloride

参考资料仅供科学研究，不可用于个人用途。

货号：BCP16483CAS号：324523-20-8纯度：98%

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CAS号	324523-20-8	货号	BCP16483
中文名	NPS-2143 hydrochloride
英文名	NPS-2143 hydrochloride
中文别名
英文别名	NPS 2143 hydrochloride;NPS2143 hydrochloride,SB 262470 HCl;
SMILES
化学名称
分子式	C24H26Cl2N2O2	分子量	445.38
纯度	98%	配送	惯例下常温包邮
产品描述	IC50 value: 43 nM(for Ca2+ receptor) Target: CaSR in vitro: NPS 2143, even when tested at much higher concentrations (3 microM), did not affect the activity of a number of other G protein-coupled receptors, including those most structurally homologous to the Ca2+ receptor. NPS 2143 stimulated parathyroid hormone (PTH) secretion from bovine parathyroid cells (EC50 of 41 nM) over a range of extracellular Ca2+ concentrations and reversed the effects of the calcimimetic compound NPS R-467 on [Ca2+]i and on secretion of PTH. The first reported calcilytic compound was NPS 2143, an orally active molecule which elicits rapid, 3- to 4-fold increases in circulating levels of PTH . in vivo: When infused intravenously in normal rats, NPS 2143 caused a rapid and large increase in plasma levels of PTH. Ca2+ receptor antagonists are termed calcilytics and NPS 2143 is the first substance (either atomic or molecular) shown to possess such activity. When administered together with an antiresorptive agen