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CAS号 | 1358099-18-9 | 货号 | BCP30323 |
中文名 | C25-140 | ||
英文名 | C25-140 | ||
中文别名 | |||
英文别名 | C25140; C25 140;TRAF6-Ubc13 inhibitor C25-140; | ||
SMILES | O=C(N1CCC(CC2=CC=CC=C2)CC1)CCC3=C(C)N(C4=NN5C(C=C4)=NN=C5C)N=C3C | ||
化学名称 | |||
分子式 | C26H31N7O | 分子量 | 457.58 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | C25-140 is a specific, first-in-class small molecule inhibitor of the TRAF6-Ubc13 interaction, binds TRAF6, inhibits TRAF6-Ubc13 interaction and TRAF6 activity; C25-140 effectively reduced TRAF6-mediated ubiquitin chain formation in vitro, impedes NF-κB activation in various immune and inflammatory signaling pathways also in primary human and murine cells; does not effect other E3 ligases (MDM2, TRIM63, ITCH, E6AP and RNF4), also does inhibit E1/E2 reactions. |
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