AN0128 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP44562CAS号：872044-70-7纯度：98%

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CAS号	872044-70-7	货号	BCP44562
中文名	AN0128
英文名	AN0128
中文别名
英文别名	CRM-0005; ONT-0001; AN-0128; CRM0005; ONT0001; AN 0128; CRM 0005; ONT 0001;
SMILES	B(C1=CC(=C(C=C1)C)Cl)(C2=CC(=C(C=C2)C)Cl)OC(=O)C3=C(C=CC=N3)O
化学名称
分子式	C20H16BCl2NO3	分子量	400.06
纯度	98%	配送	惯例下常温包邮
产品描述	AN0128 is a tumour necrosis factor alpha (TNF-α) inhibitor potentially for the treatment of atopic dermatitis. AN0128 showed promising combination of anti-bacterial and anti-inflammatory activities. This compound is now in clinical development for dermatological conditions. Daily application of AN0128 (1%) compared with controls reduced bone loss by 38 to 44% (P < 0.05), while vehicle alone had no effect (P > 0.05). The reduction in bone loss with AN0128 was similar to that achieved with a NSAID, ketorolac, and Total toothpaste containing triclosan. AN0128 also reduced the level of gingival inflammation 42% compared with the ligature only (P < 0.05), whereas vehicle alone had no effect (P > 0.05). The results indicate that AN0128 significantly reduces the formation of an inflammatory infiltrate and reduces bone loss, measured histologically and by micro-CT.