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| CAS号 | 1015787-98-0 | 货号 | BCP26079 |
| 中文名 | Gefapixant | ||
| 英文名 | Gefapixant | ||
| 中文别名 | |||
| 英文别名 | MK-7264; MK 7264; MK7264; AF-219; AF219; AF 219; RO4926219; RO-4926219; RO 4926219; | ||
| SMILES | CC(C)C1=CC(=C(C=C1OC2=CN=C(N=C2N)N)S(=O)(=O)N)OC | ||
| 化学名称 | |||
| 分子式 | C14H19N5O4S | 分子量 | 353.39 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | Gefapixant, also known as AF-219 or MK-7264, is a P2X3 receptor antagonist. Gefapixant is currently under clinical trials for chronic cough. It is believed that excessive activation of P2X3 receptors is associated with hyper-sensitization of sensory neurons. Neuronal hyper-sensitization in the airways and lungs, triggered by injury or infection, can cause an exaggerated, persistent and frequent urge to cough, so called chronic cough. P2X3 receptors seem to have a key role in mediation of cough neuronal hypersensitivity. Antagonists of P2X3 receptors such as AF-219 are a promising new group of antitussives. | ||
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