
即时询价 ×
* 必填项
请填妥以下表格,您将在一分钟内得到邮件机器人给你的报价。
Inquiry Online
×
* Required Fields.
Please complete the form below and we will contact you shortly.
Bulk Inquiry
×
* Required Fields.
Please complete the form below and we will contact you shortly.

CAS号 | 1534358-79-6 | 货号 | BCP31057 |
中文名 | COH000 | ||
英文名 | COH000 | ||
中文别名 | |||
英文别名 | COH-000; COH 000; | ||
SMILES | O=C(C1=C(C(OC)=O)C2C=CC1([C@H](NC3=CC=CC=C3)CC4=CC=C(C)C=C4)O2)OC | ||
化学名称 | |||
分子式 | C25H25NO5 | 分子量 | 419.48 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | COH000 is a highly specific covalent allosteric SUMO E1 inhibitor with an IC50 of 0.2 μM for SUMOylation in vitro. COH000 targets a cryptic pocket distinct from the active site that is completely buried in all previous SUMO E1 structures and that COH000 binding to SUMO E1 is accompanied by a network of structural changes that altogether lock the enzyme in a previously unobserved inactive conformation. |
相关产品推荐
查看更多 >Tags:COH000 供应商,COH000 购买,COH000 生产,COH000 批量,COH000 供应,COH000 订购,COH000 采购