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| CAS号 | 423148-78-1 | 货号 | BCP29044 |
| 中文名 | PYZD 4409 | ||
| 英文名 | PYZD 4409 | ||
| 中文别名 | |||
| 英文别名 | PYZD-4409;PYZD4409; | ||
| SMILES | |||
| 化学名称 | |||
| 分子式 | C14H7ClFN3O5 | 分子量 | 351.67 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | PYZD-4409 is an inhibitor of ubiquitin-activating enzyme UBA1 (E1). PYZD-4409 induced cell death in malignant cells and preferentially inhibited the clonogenic growth of primary acute myeloid leukemia cells compared with normal hematopoietic cells. Mechanistically, genetic or chemical inhibition of E1 increased expression of E1 stress markers. Moreover, BI-1 overexpression blocked cell death after E1 inhibition, suggesting ER stress is functionally important for cell death after E1 inhibition. Finally, in a mouse model of leukemia, intraperitoneal administration of PYZD - 4409 decreased tumor weight and volume compared with control without untoward toxicity. | ||
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