SZL P1-41

参考资料仅供科学研究，不可用于个人用途。

货号：BCP20701CAS号：222716-34-9纯度：98%

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CAS号	222716-34-9	货号	BCP20701
中文名	SZL P1-41
英文名	SZL P1-41
中文别名
英文别名	SZL P1 41; SZLP141; SKP2 E3 Ligase Inhibitor III;
SMILES
化学名称
分子式	C24H24N2O3S	分子量	420.52
纯度	98%	配送	惯例下常温包邮
产品描述	SZL P1-41 is Skp2 inhibitor, selectively suppresses Skp2 E3 ligase activity, but not activity of other SCF complexes. target: Skp2 In vitro: SZL P1-41 also phenocopies the effects observed upon genetic Skp2 deficiency, such as suppressing survival, Akt-mediated glycolysis as well as triggering p53-independent cellular senescence. SZL P1-41 prevent Skp2-Skp1 interactions and Skp2 SCF E3 ligase activity. The reference concentration is 5 uM. SZL P1-41 restricts cancer cell survival through triggering p53-independent cellular senescence and inhibiting aerobic glycolysis. In vivo: SZL P1-41 exhibits potent anti-tumor activities in multiple animal models and cooperates with chemotherapeutic agents to reduce cancer cell survival.