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| CAS号 | 1425381-60-7 | 货号 | BCP31675 |
| 中文名 | Gusacitinib | ||
| 英文名 | Gusacitinib | ||
| 中文别名 | |||
| 英文别名 | ASN-002; ASN 002; ASN002; | ||
| SMILES | C1CN(CCC1CC#N)C2=NC3=C(C(=O)NN=C3)C(=N2)NC4=CC=C(C=C4)N5CCC(CC5)O | ||
| 化学名称 | |||
| 分子式 | C24H28N8O2 | 分子量 | 460.54 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | Gusacitinib, also known as ASN-002, is a potent dual inhibitor of SYK/JAK kinases. ASN002 showed strong antitumor activity in both hematological and solid tumor xenograft models. ASN002 strongly suppressed the SYK and JAK family kinase signaling pathways as measured in pLAT and pSTAT assays, respectively. When profiled in a panel of 178 cell lines, ASN002 showed strong anti-proliferative activity in many lymphoid/leukemia cell lines, including SU-DHL-6, SU-DHL-4, OCI-LY10, H929 and Pfeiffer. | ||
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